Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies

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Science

3/22/2021, 11:46:17 PM


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Currently available influenza virus vaccines have inadequate effectiveness and are reformulated annually due to viral antigenic drift. Thus, development of a vaccine that confers long-term protective immunity against antigenically distant influenza virus strains is urgently needed. The highly conserved influenza virus hemagglutinin (HA) stalk represents one of the potential targets of broadly protective/universal influenza virus vaccines. https://www.nature.com/articles/s41467-018-05482-0